Evaluation and validation of biomarkers in granulomatosis with polyangiitis and microscopic polyangiitis

Conclusions We identified promising biomarkers in a literature-based review that were in part corroborated as has been shown for CRP, C3a, C5a, IL-18BP in blood and MCP-1 and C5a in urine samples. Moreover, we propose a biomarker panel comprising CRP and urinary MCP-1 in patients with AAV and renal involvement. Further investigations to confirm our preliminary results are clearly warranted, including the reliability to predict disease relapses.
Source: Nephrology Dialysis Transplantation - Category: Urology & Nephrology Authors: Tags: Acute Kidney Injury Source Type: research