Intrahepatic Toll-Like Receptor 3 in Subjects with Chronic HBV Infection and Asymptomatic Carriers, Active Chronic Hepatitis, Cirrhosis, and Hepatocellular Carcinoma

Conclusions: The AC, HCC, and Cir patients displayed increased levels of the intrahepatic TLR3 protein compared to HD and AC patients. Both activation of TLR3/INF-β signaling and inhibition of TLR3/INF-β signaling by HBV components influenced TLR3 expression in AC, ACH, Cir, and HCC subjects. However, TLR3 signaling did not influence the expression of costimulatory protein in ACH, Cir, or HCC patients. TLR3/ IFN-β signaling did influence immune responses in the livers of CHB patients.,Results: The TLR3 protein in the ACH group tended toward reduction although the P Value of the comparison between ACH group and the HD group was not statistically significant. The TLR3 levels in the HCC, AC, and Cir groups were higher than those in the HD and ACH groups. TLR3 was not interrelated with all costimulation proteins in the DCs and t-cells in all five groups. No group presented any interrelation between TLR3 and CD40, except the AC group.,Patients and Methods: Patients with ACH, Cir, HCC, and AC and healthy donors (HD) were recruited. TLR3 expression in the livers of patients were investigated using western blot analysis and immunohistochemistry. Correlations between TLR3 and costimulation proteins, specifically CD80, CD86, CD83, CD28, CTLA-4, CD40, and ICAM-1, were assessed.,Objectives: This study investigated intrahepatic TLR3 expression throughout the entire disease spectrum of CHB patients and assessed the interrelations between TLR3 and costimulation proteins.,Background: The ...
Source: Hepatitis Monthly - Category: Infectious Diseases Source Type: research