Microrna -19 A/B Mediate Grape Seed Procyanidin Extract Induced Anti-Neoplastic Effects Against Lung Cancer

Oncomirs are microRNAs (miRNA) associated with carcinogenesis and malignant transformation. They have emerged as potential molecular targets for anti-cancer therapy. We hypothesize that grape seed procyanidin extract (GSE) exerts antineoplastic effects through modulations of oncomirs and their downstream targets. We found that GSE significantly down-regulated oncomirs miR-19a and -19b in a variety of lung neoplastic cells. GSE also increased mRNA and protein levels of insulin-like growth factor II receptor (IGF-2R) and phosphatase and tensin homolog (PTEN), both predicted targets of miR-19a and -19b.

Source: The Journal of Nutritional Biochemistry - May 19, 2016 Category: Biochemistry Authors: Jenny T. Mao, Bingye Xue, Jane Smoake, Qing-Yi Lu, Heesung Park, Susanne M. Henning, Windie Burns, Alvise Bernabei, David Elashoff, Kenneth J. Serio, Larry Massie Source Type: research