Structural and biochemical characterisation of the KLHL3-WNK kinase interaction important in blood pressure regulation

This study provides further insights into how kelch-like adaptor proteins recognise their substrates and provides a structural basis for how mutations in WNK4 and KLHL3 lead to hypertension.

Source: BJ Signal - March 18, 2014 Category: Biochemistry Authors: F Schumacher, F J. Sorrell, D R. Alessi, A N. Bullock, T Kurz Tags: BJ Signal Source Type: research