Oral butyrate reduces oxidative stress in atherosclerotic lesion sites by a mechanism involving NADPH oxidase downregulation in endothelial cells

Butyrate is a 4-carbon fatty acid that has anti-inflammatory and antioxidative properties. It has been demonstrated that butyrate is able to reduce atherosclerotic development in animal models by reducing inflammatory factors. However, the contribution of its antioxidative effects of butyrate on atherogenesis has not yet been studied.

Source: The Journal of Nutritional Biochemistry - May 15, 2016 Category: Biochemistry Authors: Edenil C. Aguilar, Lana Claudinez dos Santos, Alda J. Leonel, Jamil Silvano de Oliveira, Elândia Aparecida Santos, Juliana M. Navia-Pelaez, Josiane Fernandes da Silva, Bárbara Pinheiro Mendes, Luciano S.A. Capettini, Lilian G. Teixeira, Virginia S. Lemo Source Type: research