Alternatively activated macrophages exhibit an anticalcifying activity dependent on extracellular ATP/pyrophosphate metabolism

In conclusion, increased accumulation of extracellular ATP and PPi by alternatively activated mouse M2s inhibits CPD. These results reveal novel mechanisms underlying macrophage-dependent control of intimal calcification.

Source: AJP: Cell Physiology - May 14, 2016 Category: Cytology Authors: Villa-Bellosta, R., Hamczyk, M. R., Andres, V. Tags: ARTICLES Source Type: research