HDAC2 regulates FoxO1 during RANKL-induced osteoclastogenesis

In conclusion, HDAC2 activates Akt thus suppresses FoxO1 transcription results in enhanced osteoclastogenesis. Our data imply the potential value of HDAC2 as a new target in regulating osteoclast differentiation and function.

Source: AJP: Cell Physiology - May 14, 2016 Category: Cytology Authors: Dou, C., Li, N., Ding, N., Liu, C., Yang, X., Kang, F., Cao, Z., Quan, H., Hou, T., Xu, J., Dong, S. Tags: CALL FOR PAPERS Source Type: research