Elevated G{alpha}11 expression in osteoblast lineage cells promotes osteoclastogenesis and leads to enhanced trabecular bone accrual in response to pamidronate

In conclusion, overexpression of Gα11 in osteoblastic cells promotes osteoclastogenesis by upregulation of Rankl and M-csf and bone loss by increased osteoclast resorption of the trabecular bone and cartilaginous matrix.

Source: AJP: Endocrinology and Metabolism - May 14, 2016 Category: Endocrinology Authors: Dela Cruz, A., Grynpas, M. D., Mitchell, J. Tags: Articles Source Type: research