Hodgkin lymphoma: Pathology and Biology

The Hodgkin and Reed-Sternberg (HRS) tumor cells of classical Hodgkin lymphoma (HL), as well as the lymphocyte predominant (LP) cells of nodular lymphocyte predominant HL (NLPHL) are derived from mature B cells. However, HRS cells have largely lost their B cell phenotype and show a very unusual expression of many markers of other hematopoietic cell lineages, which aids in the differential diagnosis between classical HL (cHL) and NLPHL and distinguishes cHL from all other hematopoietic malignancies.
Source: Seminars in Hematology - Category: Hematology Authors: Source Type: research