Rational design of fiber forming supramolecular structures

Recent strides in the development of multifunctional synthetic biomimetic materials through the self-assembly of multi-domain peptides and proteins over the past decade have been realized. Such engineered systems have wide-ranging application in bioengineering and medicine. This review focuses on fundamental fiber forming α-helical coiled-coil peptides, peptide amphiphiles, and amyloid-based self-assembling peptides; followed by higher order collagen- and elastin-mimetic peptides with an emphasis on chemical / biological characterization and biomimicry.

Source: Experimental Biology and Medicine - May 12, 2016 Category: Research Authors: Kumar, V. A., Wang, B. K., Kanahara, S. M. Tags: Minireview Source Type: research