Antidepressant-Like Activity of Fish Oil, with and Without Fluoxetine, in Two Behavioral Despair Paradigms in Experimental Mice

Conclusion: FO displayed anti-depressant - like action suggested by the FST and TST. Combined treatment with fluoxetine and FO did not significantly affect the performance of mice on these two tests. This suggest FO has direct bearing on the present reported behavioral paradigm of despair and helplessness. Future studies to explore molecular the molecular mechanisms behind the presently observed behavioral effect of FO in this animal model.
Source: Current Pharmacogenomics and Personalized Medicine - Category: Genetics & Stem Cells Source Type: research