Bone morphogenetic protein type I receptor inhibition induces cleft palate associated with micrognathia and cleft lower lip in mice

ConclusionThe results of this study indicate that LDN‐193189 can be used to manipulate BMP signaling by selectively targeting the BMP/Smad signaling pathway to affect palatal morphogenesis and produce phenotypes mimicking those caused by genetic mutations. This work established a novel mouse model for teratogen‐induced cleft palate. Birth Defects Research (Part A), 2016. © 2016 Wiley Periodicals, Inc.

Source: Birth Defects Research Part A: Clinical and Molecular Teratology - March 31, 2016 Category: Perinatology & Neonatology Authors: Yongzhen Lai, Changfu Xie, Shixian Zhang, Guowu Gan, Di Wu, Weihui Chen Tags: Original Research Article Source Type: research