Natriuretic peptides in percutaneous coronary intervention: Aren't they all the same?

Natriuretic peptides are hormones produced in the heart that serve as vasodilators and play a critical role in regulating fluid volume homeostasis. These peptides feature a similar amino acid ring structure that likely contributes to their biological activity. Atrial myocytes synthesize the precursor prepro atrial natriuretic peptide (ANP), which is a 151 amino acid polypeptide, that is stored in intracellular granules as the 126 amino acid proANP [1]. In response to hypervolemic states, the atrial myocytes release proANP, which is converted by the cardiac transmembrane serine protease corin to the active 28 amino acid C-terminal ANP and N-terminal (NT)-proANP [2].
Source: Cardiovascular Revascularization Medicine - Category: Cardiology Authors: Tags: Editorial Source Type: research