Neuregulin-1{beta} promotes glucose uptake via PI3K/Akt in neonatal rat cardiomyocytes

In conclusion, our study demonstrates that Nrg1β enhances glucose uptake in cardiomyocytes via ErbB2/ErbB4 heterodimers, PI3Kα, and Akt. Furthermore, although Nrg1β activates mTORC2, the resulting Akt-Ser473 phosphorylation is not essential for glucose uptake induction. These new insights into pathways whereby Nrg1β regulates glucose uptake in cardiomyocytes may contribute to the understanding of its regenerative capacity and protective function in heart failure.

Source: AJP: Endocrinology and Metabolism - May 1, 2016 Category: Endocrinology Authors: Pentassuglia, L., Heim, P., Lebboukh, S., Morandi, C., Xu, L., Brink, M. Tags: Articles Source Type: research