Soluble guanylate cyclase activation during ischemic injury in mice protects against postischemic inflammation at the mitochondrial level

In conclusion, selective activation of oxidized sGC of WT and HO-1–/– during ischemia protects against I/R-induced inflammation and preserves mucosal integrity in part by reducing pCyPD production and mPTP formation.

Source: AJP: Gastrointestinal and Liver Physiology - April 30, 2016 Category: Gastroenterology Authors: Wang, D. Z., Jones, A. W., Wang, W. Z., Wang, M., Korthuis, R. J. Tags: INFLAMMATION, IMMUNITY, AND INFECTION Source Type: research