Alternate-day fasting protects the livers of mice against high-fat diet–induced inflammation associated with the suppression of Toll-like receptor 4/nuclear factor κB signaling

Because of unhealthy lifestyles, a large number of people are suffering from hepatic lipid accumulation and nonalcoholic steatohepatitis. Energy restriction (ER) is an effective nutritional intervention for preventing chronic disease. However, poor compliance with continuous ER limits its effectiveness. As an alternative to daily ER, alternate-day fasting (ADF) may be more effective. We hypothesized that ADF would improve obesity, hyperglycemia, and insulin resistance and protect the liver against high-fat diet (HFD)–induced steatosis and inflammation.

Source: Nutrition Research - February 15, 2016 Category: Nutrition Authors: Wanwei Yang, Meng Cao, Xiaodong Mao, Xiao Wei, Xingjia Li, Guofang Chen, Jiaming Zhang, Zhiguo Wang, Jianfeng Shi, HouCai Huang, Xiaoming Yao, Chao Liu Tags: Original Research Source Type: research