Interleukin-4 receptor signaling and its binding mechanism: A therapeutic insight from inhibitors tool box
IL-4, a cytokine discovered in the 1980’s, remains in the spotlight as a target for designing a potent small molecular inhibitor. This cytokine is primarily produced by basophils, mast cells, and eosinophils, beside Th2 lymphocytes [1]. Its molecular weight varies between 12 and 20KDa because of irregular pattern of post-translational modification, particularly glycosylation. This cytokine shares most of cell surface receptors, sequence homology, intracellular signaling and limited functional effects with the IL-13 cytokine [2].
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Zaheer Ul-Haq, Sehrish Naz, M. Ahmed Mesaik Source Type: research
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