microRNAs in ischaemic cardiovascular diseases

microRNAs (miRNAs) are non-coding RNA molecules that modulate the stability and/or the translational efficiency of specific messenger RNAs. They have been shown to play a regulatory role in most biological processes and their expression is disrupted in many cardiovascular diseases. This review describes studies performed at Policlinico San Donato-IRCCS in cell cultures, animal models, and patients, showing a penetrant role of miRNAs in cell response to hypoxia and in ischaemic cardiovascular diseases. These experiments indicate miRNA as an emerging class of therapeutic targets.

Source: European Journal of Heart Failure Supplements - April 28, 2016 Category: Cardiology Authors: Greco, S., Zaccagnini, G., Voellenkle, C., Martelli, F. Tags: Articles Source Type: research