Bile acids-mediated overexpression of MUC4 via FAK-dependent c-Jun activation in pancreatic cancer

The majority of pancreatic cancer (PC) patients are clinically presented with obstructive jaundice with elevated levels of circulatory bilirubin and alkaline phosphatases. In the current study, we examined the implications of bile acids (BA), an important component of bile, on the pathophysiology of PC and investigated their mechanistic association in tumor-promoting functions. Integration of results from PC patient samples and autochthonous mouse models showed an elevated levels of BA (p

Source: Molecular Oncology - April 28, 2016 Category: Cancer & Oncology Authors: Suhasini Joshi, Eric Cruz, Satyanarayana Rachagani, Sushovan Guha, Randall E. Brand, Moorthy P. Ponnusamy, Sushil Kumar, Surinder K. Batra Source Type: research