Leaky ryanodine receptors delay the activation of store overload-induced Ca2+ release, a mechanism underlying malignant hyperthermia-like events in dystrophic muscle

We present a hypothesis that SOICR activation is required in healthy muscle and that this mechanism works suboptimally in mdx fibers to fail to limit the activation of store-operated Ca2+ entry.

Source: AJP: Cell Physiology - April 14, 2016 Category: Cytology Authors: Cully, T. R., Launikonis, B. S. Tags: Cell Signaling: Proteins, Pathways and Mechanisms CALL FOR PAPERS Source Type: research