Genetics: p53 variant increases cancer risk

Nature Reviews Cancer 16, 273 (2016). doi:10.1038/nrc.2016.45 Author: Sarah Seton-Rogers The single nucleotide polymorphism P47S (rs1800371) in TP53 is specific to populations of African descent. Jennis et al. reasoned that P47S might contribute to the increased risk of cancer in African American populations. P47S did not affect most p53 functions, but did impair
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Research Highlight Source Type: research