Evaluation of incidence and risk factors for high-dose methotrexate-induced nephrotoxicity

Conclusions Nephrotoxicity is a possible complication of therapy with high-dose methotrexate with most instances comprising grade 1–2 toxicity. Male gender, low albumin, and administration of interacting drugs or furosemide during high-dose methotrexate clearance may predispose patients to nephrotoxicity.
Source: Journal of Oncology Pharmacy Practice - Category: Cancer & Oncology Authors: Tags: Original Articles Source Type: research