Rhabdomyolysis associated with risperidone and escitalopram

Rhabdomyolysis is a potentially life‐threatening syndrome. Destruction of muscle fibers secondary to disruption of calcium homeostasis in muscle cells allows leakage of toxic cellular contents into the systemic circulation, resulting in fiber necrosis. Significant elevation of serum creatine kinase usually occurs in patients with rhabdomyolysis. This case report describes a patient who developed rhabdomyolysis after receiving concurrent risperidone and escitalopram.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fpu.30138

Source: The Brown University Psychopharmacology Update - April 21, 2016 Category: Psychiatry Authors: Y. W. Francis Lam Tags: Drug ‐Drug Interactions Source Type: research