An overview of the current methodologies used for evaluation of anti-fertility agents

Publication date: Available online 19 April 2016 Source:Asian Pacific Journal of Reproduction Author(s): Manisha Shah, Ramandeep Singh, Rashmi Shah, Satinder Kakar Discoveries in the past 2 decades have continued to improve our understanding of the mechanism of fertilization and animal models have played a significant role to define the basic mechanism of anti-fertility agents. In vivo models have been developed in the past years to study the anti-fertility agents. Methods that are used in anti-fertility study can be categorized into method including estimation of sex hormones, assessment of sperm motility and count, assessment of sperm viability and morphology, mating trial test body, sex organ weights, abortifacient activity, post-coital anti-fertility activity, effect on oestrous cycle, anti-estrogenic activity, anti-gonadotrophic effect and quantification of fructose in seminal vesicle, histopathology, and biochemical methods. This review aims to highlight some of the new and currently, used experimental models that are used for the evaluation of anti-fertility agents.
Source: Asian Pacific Journal of Reproduction - Category: Reproduction Medicine Source Type: research