Tumor-Free Transplantation of Patient-Derived Induced Pluripotent Stem Cell Progeny for Customized Islet Regeneration

This study also demonstrated that combined transgene-free reprogramming and enzymatic dissociation allows teratoma-free transplantation of iPSC progeny in the mouse model in testing the tumorigenicity of iPSC products. Further safety assessment and improvement in iPSC specification into a mature β cell phenotype would lead to safe islet replacement therapy for diabetes.

Source: Stem Cells Translational Medicine - April 17, 2016 Category: Stem Cells Authors: El Khatib, M. M., Ohmine, S., Jacobus, E. J., Tonne, J. M., Morsy, S. G., Holditch, S. J., Schreiber, C. A., Uetsuka, K., Fusaki, N., Wigle, D. A., Terzic, A., Kudva, Y. C., Ikeda, Y. Tags: Tissue Engineering and Regenerative Medicine, Pluripotent Stem Cells Source Type: research