Functional and Transcriptional Characterization of Histone Deacetylase Inhibitor-Mediated Cardiac Adverse Effects in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

This study found that human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) can predict cardiac adverse events in patients caused by HDAC inhibitors. Furthermore, transcriptional changes at the level of gene expression supported the effects on the beating properties of hiPS-CMs and highlight targets that might cause these cardiac adverse effects. hiPS-CMs represent a valuable translational model to assess HDAC inhibitor-mediated cardiotoxicity and to support development of safer HDAC inhibitors.

Source: Stem Cells Translational Medicine - April 17, 2016 Category: Stem Cells Authors: Kopljar, I., Gallacher, D. J., De Bondt, A., Cougnaud, L., Vlaminckx, E., Van den Wyngaert, I., Lu, H. R. Tags: Pluripotent Stem Cells, Cell-Based Drug Development, Screening, and Toxicology Source Type: research