Exogenous Cushing's syndrome as a result of ritonavir–budesonide interaction – A case report

We describe a case of a 43-year-old woman with HIV infection that presented with a clinical overt CS resulting from the interaction between ritonavir and intranasal budesonide at low doses. Similar cases have been described with long-term concomitant use of many glucocorticoids with ritonavir but very few concerning inhaled or intranasal budesonide. This case reinforces the importance of physicians to be aware of this interaction, promoting its early recognition and providing a careful assessment of potentially serious drug–drug interactions, especially when ritonavir is prescribed to a HIV-patient with bronchial hyperresponsiveness or rhinitis.
Source: HIV and AIDS Review - Category: Infectious Diseases Source Type: research