Myeloid-derived Suppressor Cells: The Green Light for Myeloma Immune Escape

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous, immature myeloid cell population with the ability to suppress innate and adaptive immune responses that promote tumor growth. MDSCs are increased in patients with multiple myeloma (MM) and have bidirectional interaction with tumors within the MM microenvironment. MM-MDSCs promote MM tumor growth and induce immune suppression, while conversely, MM cells induce MDSC development and survival. Although the role of MDSCs in infections, inflammatory diseases and solid tumors has been extensively characterized, their tumor-promoting and immune-suppressive role in MM and the MM microenvironment is only beginning to emerge.

Source: Blood Reviews - April 11, 2016 Category: Hematology Authors: Ehsan Malek, Marcos de Lima, John J. Letterio, Byung-Gyu Kim, James H. Finke, James J. Driscoll, Sergio A. Giralt Tags: Review Source Type: research