Plasma Klotho and Cognitive Decline in Older Adults: Findings From the InCHIANTI Study
Conclusions:
Higher plasma klotho concentrations were associated with lower risk of meaningful decline and smaller average decline in MMSE. We did not observe such findings with Trails A and B, perhaps because they test executive function and motor skills, whereas MMSE measures global cognition. Future studies should investigate mechanisms through which klotho may affect domain-specific cognitive changes.
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - Category: Geriatrics Authors: Shardell, M., Semba, R. D., Rosano, C., Kalyani, R. R., Bandinelli, S., Chia, C. W., Ferrucci, L. Tags: Research Article Source Type: research
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