Plasma Klotho and Cognitive Decline in Older Adults: Findings From the InCHIANTI Study

Conclusions: Higher plasma klotho concentrations were associated with lower risk of meaningful decline and smaller average decline in MMSE. We did not observe such findings with Trails A and B, perhaps because they test executive function and motor skills, whereas MMSE measures global cognition. Future studies should investigate mechanisms through which klotho may affect domain-specific cognitive changes.
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - Category: Geriatrics Authors: Tags: Research Article Source Type: research