Contractile Changes in the Vasculature After Subchronic Smoking: A Comparison Between Wild Type and Surfactant Protein D Knock-Out Mice

Conclusion:
The contractility to UDP was altered in the brain and heart vasculature of CSE mice. SP-D KO (both control and CSE) and CSE WT had similar changes in contractility compared to control WT.

Implications:
These results show that sub-chronic smoking induces vascular changes in the WT, mainly for the purinergic P2Y6 receptor together with minor changes for the endothelin-1 receptor. SP-D KO (both control and CSE) does not show any further changes compared to CSE WT.

Source: Nicotine and Tobacco Research - April 8, 2016 Category: Addiction Authors: Haanes, K. A., Kruse, L. S., Wulf-Johansson, H., Stottrup, C. C., Sorensen, G. L., Edvinsson, L. Tags: Brief Report Source Type: research