Influence of the A118G Polymorphism of the OPRM1 Gene and Exon 3 VNTR Polymorphism of the DRD4 Gene on Cigarette Craving After Alcohol Administration

Conclusions:
Presence of G allele of the A118G polymorphism of the OPRM1 gene may lead to greater increases in urge to smoke after a high dose of alcohol. Pharmacotherapies targeted to opiate receptors (eg, naltrexone) may be especially helpful in aiding smoking cessation among G carriers who are heavy drinkers.

Source: Nicotine and Tobacco Research - April 8, 2016 Category: Addiction Authors: Lechner, W. V., Knopik, V. S., McGeary, J. E., Spillane, N. S., Tidey, J. W., McKee, S. A., Metrik, J., Leventhal, A. M., Rohsenow, D. J., Kahler, C. W. Tags: Brief Report Source Type: research