131I-Metaiodobenzylguanidine Theranostics in Neuroblastoma: Historical Perspectives; Practical Applications

Much efficacy is gained in clinical practice if a single agent can be used for both diagnosis and therapy, a practice termed theranostics. Metaiodobenzylguanidine (mIBG), a norepinephrine analogue with high sensitivity and specificity for neuroblastoma, is an exemplar of theranostics. The physiologic biodistribution of mIBG, with absence of uptake in bone and bone marrow, allows ready detection not only of primary soft tissue tumors but also of disease in bone and marrow, the two most common sites of metastases in those with neuroblastoma.

Source: Seminars in Nuclear Medicine - April 9, 2016 Category: Nuclear Medicine Authors: Marguerite T. Parisi, Hedieh Eslamy, Julie R. Park, Barry L. Shulkin, Gregory A. Yanik Source Type: research