Vaccinations and Secondary Immune Thrombocytopenia with Antiphospholipid Antibodies by Human Papillomavirus Vaccine

A 13-year-old female patient developed immune thrombocytopenic purpura (ITP) and concomitant positive antiphospholipid antibodies (aPL) following vaccination with a quadrivalent human papillomavirus (HPV) vaccine. During the course of a disease, she developed clinical manifestation with bleeding and she was treated with intravenous immunoglobulins. Consequently, the number of her platelets remained critically low and she was put on steroids and rituximab. Since then, her platelet count remain within the normal range, but her antiphospholipid antibodies are still present.
Source: Seminars in Hematology - Category: Hematology Authors: Tags: April 2016 Suppl 1 ICIS Source Type: research