Novel regulatory mechanism in human urinary bladder: central role of transient receptor potential melastatin 4 channels in detrusor smooth muscle function

In conclusion, TRPM4 channels regulate human DSM excitability and contractility and are critical determinants of human urinary bladder function. Thus, TRPM4 channels could represent promising novel targets for the pharmacological or genetic control of overactive bladder.

Source: AJP: Cell Physiology - March 31, 2016 Category: Cytology Authors: Hristov, K. L., Smith, A. C., Parajuli, S. P., Malysz, J., Rovner, E. S., Petkov, G. V. Tags: EDITORIAL FOCUS Source Type: research