CORPUS callosum agenesis: ROLE of fetal MRI

Publication date: Available online 5 April 2016 Source:Asian Pacific Journal of Reproduction Author(s): Achour Radhouane, Neji Khaled Corpus callosum agenesis (CCA) was evaluated by ultrasound examination and magnetic resonance imaging (MRI)with many studies. Ultrasonography was able to suspect CCA by indirect signs but a definitive diagnosis of CCA was achieved in rare cases. MRI was able to diagnose complete CCA in majority of cases. Additional neurological abnormalities including heterotopia, gyration anomaly, asymmetry of the cerebral hemispheres, and Dandy-Walker variant were documented, as well as an ocular anomaly which was described, by MRI examination. Prenatal counselling for fetal agenesis of the corpus callosum is difficult as the prognosis is uncertain. The association with other cerebral abnormalities increases the likelihood of a poor outcome and ultrasonographic assessment of the fetal brain is limited. We found MRI to be a safe and useful additional procedure to complement ultrasonographic diagnosis or suspicion of CCA.
Source: Asian Pacific Journal of Reproduction - Category: Reproduction Medicine Source Type: research