Constitutive expression of genes encoding notch receptors and ligands in developing lymphocytes, nTreg cells and dendritic cells in the human thymus

Publication date: Available online 5 April 2016 Source:Results in Immunology Author(s): Luciana Bento-de-Souza, Jefferson R. Victor, Luiz C. Bento-de-Souza, Magaly Arrais-Santos, Andréia C. Rangel-Santos, Érica Pereira-Costa, Elaine Raniero-Fernandes, Maria I Seixas-Duarte, João B. Oliveira-Filho, Alberto J Silva-Duarte The thymus is the site of T cell maturation. Notch receptors (Notch1-4) and ligands (DLL1-3 and Jagged1-2) constitute one of several pathways involved in this process. Our data revealed differential constitutive expression of Notch genes and ligands in T lymphocytes and thymic dendritic cells (tDCs), suggesting their participation in human thymocyte maturation. nTreg analyses indicated that the Notch components function in parallel to promote maturation in the thymus.
Source: Results in Immunology - Category: Allergy & Immunology Source Type: research