Sprague Dawley rats: a model of successful heart aging

Publication date: Available online 1 April 2016 Source:EuPA Open Proteomics Author(s): Daniele Capitanio, Roberta Leone, Chiara Fania, Enrica Torretta, Cecilia Gelfi Aging is a universal phenomenon involving the whole body and characterized by the dysfunction of metabolic and physiological processes, leading to cardiovascular defects and heart failure. The proteomic profiles of Sprague Dawley rat hearts of 6, 22 and 30 months were analysed by DIGE and immunoblotting. Results indicate changes in myosin binding protein C, aldehyde dehydrogenase, serpins and sirtuin-3 which protects from the opening of the mitochondrial permeability transition pore by cyclophilin D increment. Conversely, an increase of fusion, a decrease of mitochondrial fission and the activation of the non-canonical autophagy pathway were observed, supporting a successful aging model. Graphical abstract
Source: EuPA Open Proteomics - Category: Bioinformatics Source Type: research