Oral administration of curcumin relieves behavioral alterations and oxidative stress in the frontal cortex, hippocampus, and striatum of ovariectomized Wistar rats

Menopause occurs gradually and is characterized by increased susceptibility to developing mood disorders. Several studies have suggested treatments based on the antioxidant properties of vitamins and herbal compounds as an alternative to hormone replacement therapies, with few or none reporting toxicity. The present study was performed to explore the effects of curcumin oral supplementation on anxiety-like behavior and oxidative stress parameters in different central nervous system (CNS) areas of ovariectomized (OVX) rats.

Source: The Journal of Nutritional Biochemistry - March 30, 2016 Category: Biochemistry Authors: Maurilio Da Silva Morrone, Carlos Eduardo Schnorr, Guilherme Antônio Behr, Juciano Gasparotto, Rafael Calixto Bortolin, Karla Suzana Moresco, Leonardo Bittencourt, Alfeu Zanotto-Filho, Daniel Pens Gelain, José Cláudio Fonseca Moreira Source Type: research