Grape seed proanthocyanidins protects against Cadmium induced oxidative pancreatitis in rats by attenuating oxidative stress, inflammation and apoptosis via Nrf-2/HO-1 signaling

The present study has been designed and carried out to explore the role of grape seed proanthocyanidins (GSP) in the pancreas of cadmium (Cd) induced cellular oxidative stress mediated toxicity in rats. Four groups of healthy rats were given oral doses of Cd (5mg/kgbw) and to identify the possible mechanism of action of GSP 100mg/kgbw was selected and was given 90 min before Cd intoxication. The causative molecular and cellular mechanism of Cd was determined using various biochemical assays, histology, western blotting and ELISA.
Source: The Journal of Nutritional Biochemistry - Category: Biochemistry Authors: Source Type: research