Metabolic transformations of dietary polyphenols: comparison between in vitro colonic and hepatic models and in vivo urinary metabolites

Studies on metabolism of polyphenols have revealed extensive transformations in the carbon backbone by colonic microbiota; however, the influence of microbial and hepatic transformations on human urinary metabolites has not been explored. Therefore, the aims of this study were: 1) to compare the in vitro microbial phenolic metabolite profile of foods and beverages with that excreted in urine of subjects consuming the same foodstuffs, and 2) to explore the role of liver on post-colonic metabolism of polyphenols by using in vitro hepatic models.
Source: The Journal of Nutritional Biochemistry - Category: Biochemistry Authors: Source Type: research