Low Molecular-Weight Fractions of Alcalase Hydrolyzed Egg Ovomucin Extract Exert Anti-Inflammatory Activity in Human Dermal Fibroblasts through the Inhibition of TNF Mediated NF-κB Pathway

Ovomucin is a mucin-like protein from egg white with a variety of biological functions. We hypothesized that ovomucin derived peptides might exert anti-inflammatory activity. The specific objectives were to test the anti-inflammatory activities of different ovomucin hydrolysates and its various fractions in human dermal fibroblasts, and to understand the possible molecular mechanisms. Three ovomucin hydrolysates were prepared and desalted; only the desalted Alcalase hydrolysate showed anti-inflammatory activity.

Source: Nutrition Research - March 28, 2016 Category: Nutrition Authors: Xiaohong Sun, Subhadeep Chakrabarti, Jun Fang, Yulong Yin, Jianping Wu Source Type: research