Nutrient-induced glucagon like peptide-1 release is modulated by serotonin

Glucagon like peptide-1 (GLP-1) and serotonin are both involved in food intake regulation. GLP-1 release is stimulated upon nutrient interaction with G-protein coupled receptors by enteroendocrine cells (EEC), whereas serotonin is released from enterochromaffin cells (ECC). The central hypothesis for the current study was that nutrient-induced GLP-1 release from EECs is modulated by serotonin through a process involving serotonin receptor interaction.This was studied by assessing the effects of serotonin reuptake inhibition by fluoxetine on nutrient-induced GLP-1, PYY and CCK release from isolated pig intestinal segments.

Source: The Journal of Nutritional Biochemistry - March 27, 2016 Category: Biochemistry Authors: Dina Ripken, Nikkie van der Wielen, Heleen M. Wortelboer, Jocelijn Meijerink, Renger F. Witkamp, Henk F.J. Hendriks Source Type: research