Immunogenicity, Inflammation, and Lipid Accumulation in Cynomolgus Monkeys Infused with a Lipidated Tetranectin-ApoA-I Fusion Protein

In conclusion, multiple infusions of lipidated TN-ApoA-I resulted in high immunogenicity, lipid accumulation and were not well tolerated in nonhuman primates.

Source: Toxicological Sciences - March 27, 2016 Category: Toxicology Authors: Regenass-Lechner, F., Staack, R. F., Mary, J.-L., Richter, W. F., Winter, M., Jordan, G., Justies, N., Langenkamp, A., Garrido, R., Albassam, M., Singer, T., Atzpodien, E.-A. Tags: High Density Lipoprotein Mimetic and Multiorgan Inflammation Source Type: research