Unbiased identification of substrates of protein tyrosine phosphatase ptp-3 in C. elegans

The leukocyte antigen related (LAR) family of receptor-like protein tyrosine phosphatases has three members in humans – PTPRF, PTPRD and PTPRS – that have been implicated in diverse processes including embryonic development, inhibition of cell growth and axonal guidance. Mutations in the LAR family are associated with developmental defects such as cleft palate as well as various cancers including breast, neck, lung, colon and brain. Although this family of tyrosine phosphatases are important for many developmental processes, little is known of their substrates.

Source: Molecular Oncology - March 24, 2016 Category: Cancer & Oncology Authors: Christopher J. Mitchell, Min-Sik Kim, Jun Zhong, Raja Sekhar Nirujogi, Anjun K. Bose, Akhilesh Pandey Source Type: research