Novel Hiv Prevention Products For Women Demonstrate Safety In Clinical Studies

Blood levels of dapivirine were low, consistent with previous studies showing dapivirine’s low systemic absorption when delivered as a microbicide. Dapivirine levels in vaginal fluids and cervical tissue – where the drug would be needed locally to prevent infection – were high. In addition, cervical tissue biopsied from women assigned to use the dapivirine-only ring and combination dapivirine-maraviroc ring showed protection against HIV when “challenged” with the virus in laboratory tests. These results further support IPM’s dapivirine-only ring, now in two parallel Phase III studies in Africa. Although maraviroc could be detected in the vaginal fluid of the women in the study, few women had maraviroc detected in the tissue. Thus, it was not surprising that the cervical tissue of women assigned to the maraviroc-only ring was not protected against infection when challenged with HIV ex vivo. You will find the original content at this website http://www.news-medical.net/news/20140305/Novel-HIV-prevention-products-for-women-demonstrate-safety-in-clinical-studies.aspx

Source: aids-write.org - March 9, 2014 Category: HIV AIDS Authors: aidswrite Tags: current news Source Type: blogs