Repositioning of drugs for intervention in tumor progression and metastasis: Old drugs for new targets

The increasing unravelling of the molecular basis of cancer offers manifold novel options for intervention strategies. However, the discovery and development of new drugs for potential clinical applications is a tremendously time-consuming and costly process. Translating a novel lead candidate compound into an approved clinical drug takes often more than a decade, and the success rate is very low due to versatile efforts including defining its pharmacokinetics, pharmacodynamics, side effects as well as lack of sufficient efficacy.
Source: Drug Resistance Updates - Category: Drugs & Pharmacology Authors: Source Type: research