The importance of p53 pathway genetics in inherited and somatic cancer genomes

Nature Reviews Cancer 16, 251 (2016).
doi:10.1038/nrc.2016.15

Authors: Giovanni Stracquadanio, Xuting Wang, Marsha D. Wallace, Anna M. Grawenda, Ping Zhang, Juliet Hewitt, Jorge Zeron-Medina, Francesc Castro-Giner, Ian P. Tomlinson, Colin R. Goding, Kamil J. Cygan, William G. Fairbrother, Laurent F. Thomas, Pål Sætrom, Federica Gemignani, Stefano Landi, Benjamin Schuster-Böckler, Douglas A. Bell & Gareth L. Bond
Decades of research have shown that mutations in the p53 stress response pathway affect the incidence of diverse cancers more than mutations in other pathways. However, most evidence is limited to somatic mutations and rare inherited mutations. Using newly abundant genomic data, we demonstrate that

Source: Nature Reviews Cancer - March 23, 2016 Category: Cancer & Oncology Authors: Giovanni StracquadanioXuting WangMarsha D. WallaceAnna M. GrawendaPing ZhangJuliet HewittJorge Zeron-MedinaFrancesc Castro-GinerIan P. TomlinsonColin R. GodingKamil J. CyganWilliam G. FairbrotherLaurent F. ThomasPål SætromFederica GemignaniStefano Landi Tags: Analysis Source Type: research