Vaccines for established cancer: overcoming the challenges posed by immune evasion

Nature Reviews Cancer 16, 219 (2016). doi:10.1038/nrc.2016.16 Authors: Sjoerd H. van der Burg, Ramon Arens, Ferry Ossendorp, Thorbald van Hall & Cornelis J. M. Melief Therapeutic vaccines preferentially stimulate T cells against tumour-specific epitopes that are created by DNA mutations or oncogenic viruses. In the setting of premalignant disease, carcinoma in situ or minimal residual disease, therapeutic vaccination can be clinically successful as monotherapy; however, in established cancers, therapeutic

http://feeds.nature.com/~r/nrc/rss/current/~3/NXkBrPGszBA/nrc.2016.16

Source: Nature Reviews Cancer - March 10, 2016 Category: Cancer & Oncology Authors: Sjoerd H. van der BurgRamon ArensFerry OssendorpThorbald van HallCornelis J. M. Melief Tags: Review Source Type: research