The IL-17A/IL-17RA axis in pulmonary defence and immunopathology

The cytokine IL-17A was first identified in 1993, and was initially called cytotoxic T lymphocyte-associated antigen 8 (CTLA-8) [1]. Today, the IL-17 cytokine family represents a wide class of pleiotropic inflammatory molecules that are structurally related. In the last two decades, researchers have particularly focused on the biological functions and regulation of IL-17A and IL-17F, although the functions of other IL-17 family members have recently become active areas of study. With respect to immunity, IL-17 cytokines modulate the outcomes of pathologic processes.
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Tags: Mini review Source Type: research