The pleiotropic effects of omega-3 docosahexaenoic acid on the hallmarks of Alzheimer's disease

Among omega-3 polyunsaturated fatty acids (PUFA), docosahexaenoic acid (DHA, 22:6n-3) is important for adequate brain development and cognition. DHA is highly concentrated in the brain and plays an essential role in brain functioning. DHA, one of the major constituents in fish fats, readily cross the blood–brain barrier (BBB) from blood to the brain. Its critical role was further supported by its reduced levels in the brain of Alzheimer's disease (AD) patients. This agrees with a potential role of DHA in memory, learning, and cognitive processes.

Source: The Journal of Nutritional Biochemistry - March 22, 2016 Category: Biochemistry Authors: Mounir Belkouch, Mayssa Hachem, Abdeljalil Elgot, Amanda Lo Van, Madeleine Picq, Michel Guichardant, Michel Lagarde, Nathalie Bernoud-Hubac Tags: Review Source Type: research